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Acne is a problem that affects millions of people. To solve it, there is a particular drug that will help eliminate the disease. Accutane is one of the most effective remedies in the fight against skin breakouts and acne. It is a synthetic stereoisomer of trans-retinoic acid (tretinoin), a systemic retinoid for acne.
Accutane should only be designated by practitioners, especially dermatologists, who work with acne. Moreover, it is advised to monitor liver functioning before medication, one month after its start, and then every three months.
Accutane is a serious acne medication. It contributes to the normalization of terminal cell differentiation, restrains the hyperproliferation of the epithelium of the excretory ducts of the sebaceous glands, and the generation of residues.
Due to this, the sebum generation is decreased, its secretion is facilitated, the composition is normalized, and the inflammatory reaction around the glands decreases. When applied externally and systemically, it has an antiseborrheic, anti-inflammatory effect. It also enhances the regeneration processes in the skin.
Proposed Clinical Use
Most often, this drug is prescribed for patients who have these cases:
- Serious types of cystic nodular acne.
- Acne which is resistant to previous medication, in particular cystic and conglobate acne, especially on the trunk.
- Acne which is accompanied by serious depression or body dysmorphic disease.
- Acne with a tendency to scarring; atypical acne, such as pyoderma of the face.
For oral intake — critical patterns of cystic nodular acne, particularly with localization on the trunk. For external intake — papulopustular acne, seborrhea, perioral dermatitis.
Before using this drug, you must pay attention to these contraindications:
- Throughout pregnancy and breastfeeding.
- Hepatic and renal failure.
- Hypervitaminosis A, severe hyperlipidemia.
- Hypersensitivity to isotretinoin.
Pay attention to the presence of critical liver and kidney malfunction, increased plasma lipids, neoplasms.
Release Forms and Dose
Accutane is most generally available in red-coated tablet form. The primary dosage is 0.5 mg/kg of body weight per day. Often, at the outset of cure, there is a short-term exacerbation of the illness. The efficacy and side effects differ in various patients. Therefore, after four weeks of therapy, a maintenance dosage of 0.1 to 1 mg/kg per day must be individually selected.
The maximum everyday dosage of 1 mg/kg can only be used for a limited time. Typically, the medication lasts 16 weeks. When assessing the therapy results, the patient’s condition often improves after the prescription is interrupted. In this regard, a second course should be appointed no earlier than after eight weeks.
The dosage for re-treatment is set according to the above recommendations. For the treatment to be effective, it is worth consulting with your doctor about the application. To get the most out of Accutane, it is also important to complete the full course of treatment.