The vital component of Lasix — furosemide — has a diuretic influence by preventing the reabsorption of sodium and chlorine ions. Lasix increases the excretion of potassium, magnesium, calcium.
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Lasix can immediately decrease blood pressure, pulmonary artery pressure, preload, and stress in the left ventricle when administered intravenously. The diuretic influence is recognized already after 5 minutes, approaching a maximum within half an hour. The continuation of the diuretic period is about 2 hours.
The principle of the performance of this medicine can be delineated. First of all, it interrupts the reabsorption of sodium and chlorine ions in the thick segment of the ascending part of Henle’s loop. Due to an improvement in the release of sodium ions, there is a secondary enhanced excretion of water and an extension in the secretion of potassium ions in the distal part of the renal tubule. At the same time, the excretion of calcium and magnesium ions progresses.
The medication has subsequent consequences due to the release of intrarenal mediators and redistribution of intrarenal blood flow. Against the environment of the program of therapy, there is no weakening of the impact.
Proposed Clinical Use
Lasix is designated to separate groups of patients. These involve people who suffer from these complications:
Edema syndrome of different sources (cardiac, hepatic, renal after the second month of pregnancy, intoxication).
Pulmonary and cerebral edema.
Nevertheless, it is worth remembering that it is worth taking this medication with attention in some cases. For this, it is essential first to consult a physician.
It is crucial to note that not all groups of people need to take this medication. Contraindications for this medicine are as follows:
Hypersensitivity to furosemide or other ingredients of the pill.
Patients allergic to sulfonamides may have cross-sensitivity to furosemide.
Patients with hypovolemia or dehydration.
People with renal failure in the form of anuria do not have a therapeutic response to furosemide.
Additionally, electrolyte disturbances should be counterbalanced before beginning therapy. During the therapy session with furosemide, it is necessary to observe electrolytes and glucose levels in the blood serum, liver, and kidney function.
Drug Forms and Dosage
Lasix is available in different forms: solution for intravenous and intramuscular administration of 10 mg / ml, tablets 40 mg, solution for injection 20 mg / 2 ml.
The setting of the treatment mode takes place individually, depending on the indications, the clinical circumstances, the patient’s age. For oral intake, the initial dosage for adults is 20-80 mg/day. Then, if necessary, the amount is gradually expanded to 600 mg/day.